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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
15.45
Human Site:
T387
Identified Species:
24.29
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
T387
D
L
S
T
G
A
A
T
P
R
T
S
Q
F
T
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
T387
D
L
S
T
G
A
A
T
P
R
T
S
Q
F
T
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
T387
N
L
S
T
G
A
A
T
P
Q
K
S
Q
F
T
Dog
Lupus familis
XP_538730
651
74149
T387
S
S
S
T
G
V
A
T
P
Q
T
P
Q
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
A379
L
C
E
D
K
L
L
A
P
K
T
P
Q
V
T
Rat
Rattus norvegicus
P54645
559
63955
F311
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
I391
S
A
E
I
G
P
N
I
A
P
K
T
E
L
A
Chicken
Gallus gallus
NP_001026680
657
74208
S393
E
S
P
L
E
E
F
S
L
N
T
H
R
T
K
Frog
Xenopus laevis
NP_001081569
651
74289
Y387
L
F
S
E
D
F
T
Y
S
S
F
E
P
H
T
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A644
Q
L
Q
K
M
Y
A
A
P
Q
D
E
R
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
S358
I
I
T
K
L
D
Y
S
P
R
S
K
S
V
R
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
R440
F
T
G
R
S
P
L
R
I
P
E
S
P
M
S
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
G707
P
V
S
T
N
L
D
G
T
Y
V
K
P
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
D192
V
L
N
D
R
G
Y
D
G
A
T
A
D
M
W
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
I379
D
T
P
A
F
N
E
I
R
D
A
Y
M
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
80
60
N.A.
26.6
0
N.A.
6.6
6.6
13.3
20
N.A.
N.A.
13.3
6.6
13.3
P-Site Similarity:
100
100
93.3
66.6
N.A.
33.3
13.3
N.A.
20
26.6
13.3
33.3
N.A.
N.A.
40
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
20
34
14
7
7
7
7
0
0
14
% A
% Cys:
0
7
0
0
7
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
20
0
0
14
7
7
7
7
0
7
7
0
7
0
7
% D
% Glu:
7
0
20
7
7
14
7
0
7
0
7
20
14
7
0
% E
% Phe:
7
7
0
0
7
7
7
7
0
0
7
0
0
27
0
% F
% Gly:
0
0
7
0
34
7
0
7
7
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% H
% Ile:
7
7
0
7
0
0
0
14
7
0
0
0
0
0
7
% I
% Lys:
0
7
0
14
7
0
7
0
0
7
14
14
0
0
7
% K
% Leu:
20
34
0
7
7
14
14
0
7
0
0
0
0
20
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
7
14
7
% M
% Asn:
7
0
7
0
7
7
7
0
0
7
0
0
0
0
0
% N
% Pro:
7
0
14
0
0
14
0
0
47
14
0
14
20
0
0
% P
% Gln:
7
0
7
0
0
0
0
0
0
20
0
0
34
0
0
% Q
% Arg:
0
0
0
7
7
0
0
7
7
20
0
0
14
0
7
% R
% Ser:
14
14
40
0
7
0
0
14
7
7
14
27
7
0
7
% S
% Thr:
0
14
7
34
0
0
7
27
7
0
40
7
0
7
34
% T
% Val:
7
7
0
7
0
7
0
0
0
0
7
0
0
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
7
14
7
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _